Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.
about
Thrombin receptors and their antagonists: an update on the patent literatureAbsence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosisPulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.Coagulation and autoimmunity in scleroderma interstitial lung disease.Novel therapeutic approaches for pulmonary fibrosis.Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease.Effects of inhaled thrombin receptor agonists in mice.Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: an observational studyActivation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblastsNormal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis.Disorders of lung matrix remodeling.Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switchingAngiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways.The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.Pediatric lung disease: from proteinases to pulmonary fibrosis.Molecular and cellular mechanisms of pulmonary fibrosis.Pharmacologic therapies for idiopathic pulmonary fibrosis, past and future.Connective tissue growth factor: a role in airway remodelling in asthma?Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.Advances in mechanisms of repair and remodelling in acute lung injury.Cardiac tissue factor: roles in physiology and fibrosis.Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.The pathogenesis of idiopathic pulmonary fibrosis.Blood coagulation factor Xa as an emerging drug target.The role of macrophages in healing the wounded lung.Sphingolipid regulation of tissue fibrosisNew treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research.Advances in the treatment of idiopathic pulmonary fibrosis.Innate immunity, hemostasis and matrix remodeling: PTX3 as a link.Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis.Tissue remodelling in pulmonary fibrosis.Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells.
P2860
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P2860
Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@en
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@nl
type
label
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@en
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@nl
prefLabel
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@en
Direct thrombin inhibition red ...... in-induced pulmonary fibrosis.
@nl
P2093
P2860
P1476
Direct thrombin inhibition red ...... cin-induced pulmonary fibrosis
@en
P2093
D C Howell
G J Laurent
N R Goldsack
R C Chambers
R P Marshall
P2860
P304
P356
10.1016/S0002-9440(10)62525-4
P407
P577
2001-10-01T00:00:00Z