The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
about
Short linear motifs - ex nihilo evolution of protein regulationQuantitative framework for ordered degradation of APC/C substrates.Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry.Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationA Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly CheckpointExperimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for badDistinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Molecular basis of APC/C regulation by the spindle assembly checkpoint.RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexKinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegansTargeting Cdc20 as a novel cancer therapeutic strategy.High-throughput methods for identification of protein-protein interactions involving short linear motifs.Structure of an intermediate conformer of the spindle checkpoint protein Mad2Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experimentsControl of APC/C-dependent ubiquitin chain elongation by reversible phosphorylationProbing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated ProteolysisBubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancerA novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1.SLiMScape 3.x: a Cytoscape 3 app for discovery of Short Linear Motifs in protein interaction networks.SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions.The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Evidence that HIV-1 restriction factor SAMHD1 facilitates differentiation of myeloid THP-1 cells.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Regulation of Cell Division.Playing polo during mitosis: PLK1 takes the lead.Dynamic ubiquitin signaling in cell cycle regulation.The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Delayed APC/C activation extends the first mitosis of mouse embryos.Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling.Basis of catalytic assembly of the mitotic checkpoint complex.A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.Bub1/BubR1: swiss army knives at kinetochores.Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
P2860
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P2860
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
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2015年學術文章
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name
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@en
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@nl
type
label
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@en
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@nl
prefLabel
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@en
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@nl
P2093
P2860
P50
P1433
P1476
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators
@en
P2093
Anja Hagting
Barbara Di Fiore
Daisuke Izawa
Toby J Gibson
P2860
P304
P356
10.1016/J.DEVCEL.2015.01.003
P407
P577
2015-02-01T00:00:00Z