Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles.
about
CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide productionPen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinAssembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.A simple detection method for low-affinity membrane protein interactions by baculoviral display.Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.A novel screening system for claudin binder using baculoviral display.Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Baculovirus as versatile vectors for protein expression in insect and mammalian cells.Three-dimensional structure of the signal peptide peptidasePhenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1The keystone of Alzheimer pathogenesis might be sought in Aβ physiologyThe role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidAlzheimer's disease: cholesterol, membrane rafts, isoprenoids and statinsA faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substratesDeducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Glu-333 of nicastrin directly participates in gamma-secretase activity.Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.The structure and function of Alzheimer's gamma secretase enzyme complex.Proof of concept for claudin-targeted drug development.Structural biology of presenilins and signal peptide peptidases.Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.The method used to culture host cells (Sf9 cells) can affect the qualities of baculovirus budding particles expressing recombinant proteins.Direct and potent regulation of gamma-secretase by its lipid microenvironment.Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.Efficient production of a mature and functional gamma secretase protease
P2860
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P2860
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Selective reconstitution and r ...... budded baculovirus particles.
@en
Selective reconstitution and r ...... budded baculovirus particles.
@nl
type
label
Selective reconstitution and r ...... budded baculovirus particles.
@en
Selective reconstitution and r ...... budded baculovirus particles.
@nl
prefLabel
Selective reconstitution and r ...... budded baculovirus particles.
@en
Selective reconstitution and r ...... budded baculovirus particles.
@nl
P2093
P2860
P356
P1476
Selective reconstitution and r ...... budded baculovirus particles.
@en
P2093
Ikuo Hayashi
Noriko Isoo
Rie Fukuda
Takao Hamakubo
Takeshi Iwatsubo
Tatsuhiko Kodama
Yasuomi Urano
P2860
P304
38040-38046
P356
10.1074/JBC.M405597200
P407
P577
2004-06-23T00:00:00Z