Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. - Wikidata - awgldk - TriplyDB

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

http://www.wikidata.org/entity/Q42064207

about

Mst1 and Mst2 kinases: regulations and diseases Yap1 acts downstream of α-catenin to control epidermal proliferation Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2 Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP The hippo signaling pathway in development and cancer α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1 The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair The Roles of NDR Protein Kinases in Hippo Signalling Mechanisms of Hippo pathway regulation Emerging role of Hippo pathway in gastric and other gastrointestinal cancers MST kinases in development and disease Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy YAP and TAZ: a nexus for Hippo signaling and beyond Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice Actin cytoskeleton regulates Hippo signaling Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.

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P2860

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

http://www.wikidata.org/entity/Q42064207

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

@zh-tw

2009年论文

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2009年论文

@zh

2009年论文

@zh-cn

name

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@en

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@nl

type

label

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@en

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@nl

prefLabel

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@en

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@nl

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P356

J.CCR.2009.09.026

P1433

P1476

Mst1 and Mst2 maintain hepatoc ...... tivation of the Yap1 oncogene.

@en

P2093

Claudius Conrad

http://www.w3.org/2001/XMLSchema#string

Fan Xia

http://www.w3.org/2001/XMLSchema#string

Gregory Y Lauwers

http://www.w3.org/2001/XMLSchema#string

Jeannie T Lee

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Ji-Sun Park

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Joseph Avruch

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Nabeel Bardeesy

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Wolfgang Thasler

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Yi Yin

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P2860

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

TEAD mediates YAP-dependent gene induction and growth control

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

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425-438

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10.1016/J.CCR.2009.09.026

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5

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16

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Nabeel Bardeesy

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2009-11-01T00:00:00Z

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38057156

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19878874

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P921

hepatocyte homeostasis

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3023165

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