Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3 - Wikidata - awgldk - TriplyDB

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

http://www.wikidata.org/entity/Q42077427

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Strategies for treatment in Alexander disease Mouse models of polyglutamine diseases: review and data table. Part I Mechanisms of RNA-induced toxicity in CAG repeat disorders Autophagy and neurodegeneration Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Autophagy modulation as a potential therapeutic target for diverse diseases Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Therapeutic targeting of autophagy in neurodegenerative and infectious diseases Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.Early autophagic response in a novel knock-in model of Huntington disease Milestones in ataxia Signals from the lysosome: a control centre for cellular clearance and energy metabolism.The biology of proteostasis in aging and disease.Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1.Macroautophagy abnormality in essential tremor.Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration The role of CELF proteins in neurological disorders.Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics Hypertonic stress induces rapid and widespread protein damage in C. elegans.The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.Toward understanding Machado-Joseph disease Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.CUG-BP, Elav-like family (CELF)-mediated alternative splicing regulation in the brain during health and disease.TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases.Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

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Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

http://www.wikidata.org/entity/Q42077427

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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type

label

Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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prefLabel

Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

@en

Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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Autophagy induction reduces mu ...... spinocerebellar ataxia type 3

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David C Rubinsztein

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Fiona M Menzies

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Jeannette Huebener

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Maurizio Renna

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Michael Bonin

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P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

A new mathematical model for relative quantification in real-time RT-PCR

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast.

Mechanisms of resistance to rapamycins

Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Pt 1

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133

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20007218

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2801325

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