The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
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c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xLBH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cellsT cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cellsElevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.The essential role of evasion from cell death in cancer.MCL1 enhances the survival of CD8+ memory T Cells after viral infection.MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthoodReduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.ERK1 is important for Th2 differentiation and development of experimental asthma.Decision checkpoints in the thymus.Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.Delving deeper: MCL-1's contributions to normal and cancer biology.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersMcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection.Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice.Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.Curing HIV: Pharmacologic approaches to target HIV-1 latency.Roles of autophagy in lymphocytes: reflections and directions.MicroRNAs in cardiac apoptosis.Apoptosis and autophagy in the regulation of T lymphocyte functionTranscription factor network regulating CD(+)CD8(+) thymocyte survival.IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasisThe contribution of autophagy to lymphocyte survival and homeostasis.Role of T cell death in maintaining immune tolerance during persistent viral hepatitis.Small molecule Mcl-1 inhibitors for the treatment of cancer.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors.Bcl-2 proteins in development, health, and disease of the hematopoietic system.HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors.The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.
P2860
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P2860
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@en
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@nl
type
label
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@en
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@nl
prefLabel
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@en
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@nl
P2860
P1476
The anti-apoptotic Bcl-2 famil ...... e survival at multiple stages.
@en
P2093
Alexis Dunkle
You-Wen He
P2860
P304
P356
10.4049/JIMMUNOL.181.1.521
P407
P577
2008-07-01T00:00:00Z