Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.
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La FAM fatale: USP9X in development and diseaseFas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors.Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.The essential role of evasion from cell death in cancer.Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthoodEndogenous Bcl-xL is essential for Myc-driven lymphomagenesis in miceMechanistic rationale for MCL1 inhibition during androgen deprivation therapy.Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in miceProgrammed cell death in animal development and disease.Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cellsThe BCL-2 protein family, BH3-mimetics and cancer therapy.Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in miceLoss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)Oncogenes in cell survival and cell death.Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.Delving deeper: MCL-1's contributions to normal and cancer biology.Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune diseaseBif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagyFoxO3 suppresses Myc-driven lymphomagenesis.MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eμ-myc lymphoma.Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response.The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesProgramming cancer cells for high expression levels of Mcl1.Getting away with murder: how does the BCL-2 family of proteins kill with immunity?Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Regulation of hematopoietic stem cell integrity through p53 and its related factors.Survival control of malignant lymphocytes by anti-apoptotic MCL-1.The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis
P2860
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P2860
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@ast
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@en
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@nl
type
label
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@ast
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@en
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@nl
prefLabel
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@ast
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@en
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@nl
P2093
P2860
P50
P1433
P1476
Elevated Mcl-1 perturbs lympho ...... and enhances drug resistance.
@en
P2093
Cassandra J Vandenberg
Clare L Scott
Marian L Turner
Mary L Bath
P2860
P304
P356
10.1182/BLOOD-2010-04-281071
P407
P577
2010-07-14T00:00:00Z