Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
about
Crystal structure of unautoprocessed precursor of subtilisin from a hyperthermophilic archaeon: evidence for Ca2+-induced foldingEnzymatic activity of sperm proprotein convertase is important for mammalian fertilizationFunctional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.Modulating furin activity with designed mini-PDX peptides: synthesis and in vitro kinetic evaluation.Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasisCa2+-dependent maturation of subtilisin from a hyperthermophilic archaeon, Thermococcus kodakaraensis: the propeptide is a potent inhibitor of the mature domain but is not required for its foldingSynthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamineHighly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.Crystallization and preliminary X-ray diffraction study of an active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeonThe mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin.Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.Identification of furin pro-region determinants involved in folding and activation.Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide.A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
P2860
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P2860
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@en
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@nl
type
label
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@en
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@nl
prefLabel
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@en
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@nl
P2860
P356
P1433
P1476
Synthetic peptides derived fro ...... ent inhibitors of both enzymes
@en
P2093
Ajoy Basak
Claude Lazure
P2860
P304
P356
10.1042/BJ20030120
P407
P577
2003-07-01T00:00:00Z