Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.

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Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.

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2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Discovery of 3-aminopicolinami ...... exposure and in vivo efficacy.

@en

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4

@nl

type

Item

label

Discovery of 3-aminopicolinami ...... exposure and in vivo efficacy.

@en

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4

@nl

prefLabel

Discovery of 3-aminopicolinami ...... exposure and in vivo efficacy.

@en

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4

@nl

P1476

Discovery of 3-aminopicolinami ...... exposure and in vivo efficacy.

@en

P2093

Analisa D Thompson

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Anna L Blobaum

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Carrie K Jones

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Corey R Hopkins

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Darren W Engers

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J Scott Daniels

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Joseph D Panarese

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Patrick R Gentry

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Pedro M Garcia-Barrantes

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Rocco D Gogliotti

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P2860

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment

Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.

Circuits and circuit disorders of the basal ganglia.

Functional neuroanatomy of the basal ganglia in Parkinson's disease.

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recept

P304

2915-2919

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P31

scholarly article

P356

10.1016/J.BMCL.2016.04.041

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P407

English

P433

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P478

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P50

Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

P577

2016-04-19T00:00:00Z

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P698

27131990

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P932

4899947

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