Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
about
Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseDevelopment of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsNew pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors.Are GPCRs still a source of new targets?Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
P2860
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P2860
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
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2012 nî lūn-bûn
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2012年学术文章
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name
Continued optimization of the ...... arinic acetylcholine receptor.
@en
Continued optimization of the ...... arinic acetylcholine receptor.
@nl
type
label
Continued optimization of the ...... arinic acetylcholine receptor.
@en
Continued optimization of the ...... arinic acetylcholine receptor.
@nl
prefLabel
Continued optimization of the ...... arinic acetylcholine receptor.
@en
Continued optimization of the ...... arinic acetylcholine receptor.
@nl
P2093
P2860
P50
P1476
Continued optimization of the ...... arinic acetylcholine receptor.
@en
P2093
Brian A Chauder
Bruce J Melancon
Douglas J Sheffler
Evan P Lebois
Hyekyung P Cho
J Scott Daniels
James C Tarr
Michael R Wood
Rocco D Gogliotti
Ryan D Morrison
P2860
P304
P356
10.1016/J.BMCL.2012.03.088
P407
P577
2012-03-29T00:00:00Z