Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function - Wikidata - awgldk - TriplyDB

Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function

Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function

http://www.wikidata.org/entity/Q42165269

about

Podocytes Podocyte endocytosis in the regulation of the glomerular filtration barrier The function of endocytosis in podocytes Signaling by the phosphoinositide 3-kinase family in immune cells Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.Glomerular proteinuria: a complex interplay between unique players.Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Investigating mechanisms of chronic kidney disease in mouse models Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.Signaling from the podocyte intercellular junction to the actin cytoskeleton.Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney.New insight into the intracellular roles of class II phosphoinositide 3-kinases.Class II phosphoinositide 3-kinase C2alpha: what we learned so far Podocyte-actin dynamics in health and disease.Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.Conditional knockout of pik3c3 causes a murine muscular dystrophy.Dentin Dysplasia in Notum Knockout Mice.Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability.The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

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Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function

http://www.wikidata.org/entity/Q42165269

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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name

Requirement for class II phosp ...... merular structure and function

@en

Requirement for class II phosp ...... merular structure and function

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type

label

Requirement for class II phosp ...... merular structure and function

@en

Requirement for class II phosp ...... merular structure and function

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prefLabel

Requirement for class II phosp ...... merular structure and function

@en

Requirement for class II phosp ...... merular structure and function

@nl

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Molecular and Cellular Biology

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Requirement for class II phosp ...... merular structure and function

@en

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Christopher M DaCosta

http://www.w3.org/2001/XMLSchema#string

David P Harris

http://www.w3.org/2001/XMLSchema#string

David R Powell

http://www.w3.org/2001/XMLSchema#string

Gwenn M Hansen

http://www.w3.org/2001/XMLSchema#string

Jan Domin

http://www.w3.org/2001/XMLSchema#string

Juliane Humphries

http://www.w3.org/2001/XMLSchema#string

Kanchan G Jhaver

http://www.w3.org/2001/XMLSchema#string

Karen Moberg

http://www.w3.org/2001/XMLSchema#string

Marie Wims

http://www.w3.org/2001/XMLSchema#string

Melanie K Shadoan

http://www.w3.org/2001/XMLSchema#string

P2860

Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

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63-80

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scholarly article

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10.1128/MCB.00468-10

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1

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31

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2010-10-25T00:00:00Z

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47544244

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20974805

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3019860

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