Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.
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KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progressionCalcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsAn essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55RRIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesT cell activationMolecular mechanisms for adaptive tolerance and other T cell anergy modelsThe M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytesRas family of small GTPases in immunity and inflammationPI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsRap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cellsRIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugationInvolvement of raft-like plasma membrane domains of Entamoeba histolytica in pinocytosis and adhesion.The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.Radil controls neutrophil adhesion and motility through β2-integrin activation.WNK1 kinase balances T cell adhesion versus migration in vivoActin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityCell signaling and transcription factor genes expressed during whole body regeneration in a colonial chordate.Dok-4 is a novel negative regulator of T cell activation.Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells.Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion.The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion.Sin: good or bad? A T lymphocyte perspective.The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase.Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking.AF6 negatively regulates Rap1-induced cell adhesion.A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathwaysSuppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area.
P2860
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P2860
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@en
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@nl
type
label
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@en
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@nl
prefLabel
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@en
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@nl
P2093
P356
P1433
P1476
Rap1A positively regulates T c ...... hibiting lymphocyte signaling.
@en
P2093
Eric Sebzda
Madelon Bracke
Nancy Hogg
Tamara Tugal
P304
P356
10.1038/NI765
P407
P577
2002-02-11T00:00:00Z