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A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imagingIn vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasisHighly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferaseThe Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulenceCentromere-associated topoisomerase activity in bloodstream form Trypanosoma bruceipTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi.Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major featureHuprines as a new family of dual acting trypanocidal-antiplasmodial agentsVitamin C biosynthesis in trypanosomes: a role for the glycosome.TrypanoCyc: a community-led biochemical pathways database for Trypanosoma bruceiLimited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activityA mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.Validation of spermidine synthase as a drug target in African trypanosomes.Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathyEvidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.Biological factors that impinge on Chagas disease drug development.Mechanism of genetic exchange in American trypanosomes.The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements.Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase.Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.Genetic techniques in Trypanosoma cruzi.Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activityFunctional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum.Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study.Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression.Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.Pathogen imaging applications.Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.Imaging the development of chronic Chagas disease after oral transmission
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description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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type
label
Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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prefLabel
Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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Martin C Taylor
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P106
P1153
57195676136
P21
P2798
P31
P496
0000-0003-4147-0693