Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
about
A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalizationMatrix metalloproteinases in stem cell regulation and cancerPAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasisTurning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug developmentDevelopmental role of zebrafish protease-activated receptor 1 (PAR1) in the cardio-vascular systemProteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cellsProteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connectionSignal transduction by protease-activated receptorsN-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalizationIdentification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for antiangiogenic therapy.Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin.Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation.Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP functionThe role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft modelAllosteric modulation of protease-activated receptor signaling.Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention.Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducinsStreptococcal SpeB cleaved PAR-1 suppresses ERK phosphorylation and blunts thrombin-induced platelet aggregation.Regulation of protease-activated receptor signaling by post-translational modifications.Targeting protease-activated receptor-1 with cell-penetrating pepducins in lung cancer.Relation of baseline plasma MMP-1 levels to long-term all-cause mortality in patients with known or suspected coronary artery disease referred for coronary angiography.Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functionsStreptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from plateletsMegakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events.Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling.Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia.Collagen fibril surface displays a constellation of sites capable of promoting fibril assembly, stability, and hemostasisTargeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor MimeticsPlatelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct ExpansionA matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.Matrix metalloprotease-1a promotes tumorigenesis and metastasis.Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects.Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis.Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.Matrix metalloproteases and PAR1 activation.Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease.
P2860
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P2860
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@en
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@nl
type
label
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@en
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@nl
prefLabel
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@en
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@nl
P2093
P2860
P1433
P1476
Platelet matrix metalloproteas ...... PAR1 at a cryptic ligand site
@en
P2093
Andrew J Leger
Athan Kuliopulos
Boris Tchernychev
Katie O'Callaghan
Lidija Covic
Nicole C Kaneider
Vishal Trivedi
P2860
P304
P356
10.1016/J.CELL.2009.02.018
P407
P577
2009-04-01T00:00:00Z