Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
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Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosisTB drug development: immunology at the tableMycobacterial genes essential for the pathogen's survival in the host(1)H-NMR-Based Endometabolome Profiles of Burkholderia cenocepacia Clonal Variants Retrieved from a Cystic Fibrosis Patient during Chronic InfectionCombining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug DiscoveryHigh Persister Mutants in Mycobacterium tuberculosisEmerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.Metabolic Perspectives on PersistenceMycobacterial Cultures Contain Cell Size and Density Specific Sub-populations of Cells with Significant Differential Susceptibility to Antibiotics, Oxidative and Nitrite StressNew Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in MycobacteriaTarget-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosisProteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics--Fluoroquinolones.Antibiotic efficacy is linked to bacterial cellular respiration.Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis.Metabolic plasticity of central carbon metabolism protects mycobacteria.E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular DamageCentral Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo.Role of Glyoxylate Shunt in Oxidative Stress ResponseMycobacteriophage SWU1 gp39 can potentiate multiple antibiotics against Mycobacterium via altering the cell wall permeability.Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Superoxide Generation and Its Involvement in the Growth of Mycobacterium smegmatis.Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death.Hijacking and Use of Host Lipids by Intracellular Pathogens.Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review.A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteus.Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Kunkel Lecture: Fundamental immunodeficiency and its correction.Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis.Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis.Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide.Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility.Metabolomic analysis based on 1H-nuclear magnetic resonance spectroscopy metabolic profiles in tuberculous, malignant and transudative pleural effusionThe role of metabolomics in tuberculosis treatment research.Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.
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P2860
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@en
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@nl
type
label
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@en
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@nl
prefLabel
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@en
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@nl
P2093
P2860
P356
P1476
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
@en
P2093
Carl Nathan
Kyu Y Rhee
Madhumitha Nandakumar
P2860
P2888
P356
10.1038/NCOMMS5306
P407
P577
2014-06-30T00:00:00Z