Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
about
TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpainA review of the past, present, and future directions of neoplasiaComing of Age in the Life ofNeoplasia: Where We Have Been and Where We Are GoingCalpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration.The growth and tumor suppressors NORE1A and RASSF1A are targets for calpain-mediated proteolysis.Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration.Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cellsSystems microscopy approaches to understand cancer cell migration and metastasis.Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression.Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2.Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinomaCalpains as potential anti-cancer targetsCapn4 is a marker of poor clinical outcomes and promotes nasopharyngeal carcinoma metastasis via nuclear factor-κB-induced matrix metalloproteinase 2 expressionFluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different speciesA protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cellsThe hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activityAntiprotease therapy in cancer: hot or not?Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover.The calpain system and cancer.Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3.Increased expression of Capn4 is associated with the malignancy of human glioma.Calpains are required for invasive and metastatic potentials of human HCC cells.Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.Long term anoxia in rainbow trout investigated by 2-DE and MS/MS.Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains.Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.
P2860
Q24633941-6ABD4554-738B-4A0E-A864-E578CBBB29BDQ28389391-5705DC6C-0F1E-415C-8326-0468C2705C17Q28389985-DF35284C-8EF5-4F2A-86AD-C143A2F44FA9Q28395095-D8A38247-EA97-4DCB-B05C-AB9F3A187622Q30427752-183EE1F0-E37D-47B9-83F6-1699AC12871EQ30440607-15661185-8C32-4610-9E75-ED191891925BQ30447028-F80730FA-62EA-4E93-B0F6-281B4A2340BCQ30494157-F124157A-142A-4479-A5D1-6A7439C83D7FQ33648384-84284901-1D1D-4538-9F08-3BE762562CE7Q34106013-973B4FD0-E219-4C87-AA5B-A480EFEB2B20Q34410183-E7B2FED2-628E-4F53-81AC-69B5C5F8EC84Q34425717-0582BBF7-9A39-4CC5-8758-8EB3BAF47CDFQ34563366-9AF2868F-F05C-4E92-BB72-1CACF3CDF1E8Q34793288-A1A06791-258C-47B4-A039-C874664ACB0EQ35051827-85FD3F01-4454-477F-BBDA-3DE25B962964Q35604895-850BD669-1123-4C20-AAC8-DD2CE3BDC41FQ35918764-F1406CE3-4068-49F2-93C8-0252DDD50DBDQ36026346-A4AE6D80-6655-4608-A3B0-C37359342772Q36144298-76BA9904-5111-451A-96A3-28B4220C80A7Q36404904-8AAC6F15-403C-4E99-BD2F-0492EF6DF7F0Q36407244-22DEF016-BB69-4D16-B178-F344B08735E6Q36491754-7654B07A-C1D1-48A9-83A3-6754971F3A9EQ37310983-AB80958A-5E4A-4019-A93A-3E0999EEC192Q37867486-F95B5654-5425-44D3-9A09-8F549E559C91Q38614956-8A2267E2-DC71-4333-80CE-36E2030DAF51Q38853201-5E7CE092-3D1C-4AFA-B84A-9F9572D088D0Q39015599-092E9269-631F-47D3-8FAD-FEBC8A157422Q39144278-55A3324C-EB01-4AF0-A77D-096BF7B308D9Q39912728-CD30EF30-FBB6-498F-8AD8-EADD8E3715FBQ40018079-F7FBB392-4F45-4985-9099-16231F5CF4CAQ40230605-1928008F-8D5E-4EC1-A93D-6D71023595FFQ51617592-EA0AEEAC-7999-47C7-9234-7CA1AA4B46CC
P2860
Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Calpain activity is generally ...... -specific biological functions
@en
Calpain activity is generally ...... -specific biological functions
@nl
type
label
Calpain activity is generally ...... -specific biological functions
@en
Calpain activity is generally ...... -specific biological functions
@nl
prefLabel
Calpain activity is generally ...... -specific biological functions
@en
Calpain activity is generally ...... -specific biological functions
@nl
P2093
P2860
P1433
P1476
Calpain activity is generally ...... -specific biological functions
@en
P2093
B D Fonseca
N O Carragher
P2860
P356
10.1016/S1476-5586(04)80053-8
P577
2004-01-01T00:00:00Z