Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
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Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta productionFocal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell DissociationLoss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseAssembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Sortilin Fragments Deposit at Senile Plaques in Human CerebrumDetermination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex.Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.Bacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Substrate specificity of gamma-secretase and other intramembrane proteases.Presenilin: RIP and beyond.Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.Glu-333 of nicastrin directly participates in gamma-secretase activity.The structure and function of Alzheimer's gamma secretase enzyme complex.The many substrates of presenilin/γ-secretase.The physiology of the β-amyloid precursor protein intracellular domain AICD.The Role of SORL1 in Alzheimer's Disease.Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.Genetic epistasis regulates amyloid deposition in resilient aging.SorLA complement-type repeat domains protect the amyloid precursor protein against processing.Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway.SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1.Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Dimerization of sortilin regulates its trafficking to extracellular vesicles.Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese.Targeting amyloid precursor protein.
P2860
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P2860
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@en
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@nl
type
label
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@en
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@nl
prefLabel
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@en
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@nl
P2093
P2860
P356
P1476
Sortilin, SorCS1b, and SorLA V ...... el gamma-secretase substrates.
@en
P2093
Andrew C Nyborg
Craig W Zwizinski
James J Lah
Thomas B Ladd
Todd E Golde
P2860
P2888
P356
10.1186/1750-1326-1-3
P577
2006-06-12T00:00:00Z
P5875
P6179
1002722766