Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin.
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Profile of Susan Band HorwitzThe binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic densityTubulin-interactive natural products as anticancer agentsSelective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell linesA natural love of natural products.Posttranslational modification of tubulin by palmitoylation: I. In vivo and cell-free studiesPosttranslational modification of tubulin by palmitoylation: II. Identification of sites of palmitoylation.Fluorescent taxoids as probes of the microtubule cytoskeleton.TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: a non-randomized retrospective study.Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.Methods in tubulin proteomicsMechanisms of Taxol resistance related to microtubules.Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.Chemistry and chemical biology of taxane anticancer agents.Recent advances in the study of the bioactive conformation of taxolConformationally Constrained and Nanoparticle Targeted Paclitaxels.A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin.The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosisSelective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumorsAssociation of mitogen-activated protein kinases with microtubules in mouse macrophages.Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypesTaccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.Can the status of the breast and ovarian cancer susceptibility gene 1 product (BRCA1) predict response to taxane-based cancer therapy?Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.Structural studies of taxol analogues for drug discovery.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway.Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage.Association of ABCB1, β tubulin I, and III with multidrug resistance of MCF7/DOC subline from breast cancer cell line MCF7.Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies.Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines.Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6.Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae.
P2860
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P2860
Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Characterization of the taxol binding site on the microtubule. 2-
@nl
Characterization of the taxol ...... cids 217-231) of beta-tubulin.
@en
type
label
Characterization of the taxol binding site on the microtubule. 2-
@nl
Characterization of the taxol ...... cids 217-231) of beta-tubulin.
@en
prefLabel
Characterization of the taxol binding site on the microtubule. 2-
@nl
Characterization of the taxol ...... cids 217-231) of beta-tubulin.
@en
P2093
P2860
P356
P1476
Characterization of the taxol ...... cids 217-231) of beta-tubulin.
@en
P2093
P2860
P304
20235-20238
P356
10.1074/JBC.270.35.20235
P407
P577
1995-09-01T00:00:00Z