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Marginal level dystrophin expression improves clinical outcome in a strain of dystrophin/utrophin double knockout miceQuantitative phenotyping of Duchenne muscular dystrophy dogs by comprehensive gait analysis and overnight activity monitoringAnimal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapyNight Activity Reduction is a Signature Physiological Biomarker for Duchenne Muscular Dystrophy Dogs.Perspectives on best practices for gene therapy programsEctopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice.Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy.Full-length dystrophin reconstitution with adeno-associated viral vectorsIncorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo.Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin.Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy.Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1, -6, and -9 in neonatal dogs.Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction.Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin-null micePhenotyping cardiac gene therapy in miceThe passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx miceCharacterization of 65 epitope-specific dystrophin monoclonal antibodies in canine and murine models of duchenne muscular dystrophy by immunostaining and western blot.The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx MiceAAV-microdystrophin therapy improves cardiac performance in aged female mdx mice.AAV-8 is more efficient than AAV-9 in transducing neonatal dog heart.Duchenne muscular dystrophy gene therapy in the canine model.The evolution of heart gene delivery vectorsGender differences in contractile and passive properties of mdx extensor digitorum longus muscle.Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs.Recombinant adeno-associated viral vector production and purification.Humoral immunity to AAV-6, 8, and 9 in normal and dystrophic dogsContemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus.Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.Non-invasive evaluation of muscle disease in the canine model of Duchenne muscular dystrophy by electrical impedance myography.Perspective on Adeno-Associated Virus Capsid Modification for Duchenne Muscular Dystrophy Gene TherapyChallenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy.Truncated dystrophins reduce muscle stiffness in the extensor digitorum longus muscle of mdx mice.Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.Synthetic intron improves transduction efficiency of trans-splicing adeno-associated viral vectors.Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy
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P50
description
onderzoeker
@nl
researcher
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հետազոտող
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name
Dongsheng Duan
@ast
Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
@nl
Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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Dongsheng Duan
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P106
P1153
7007026237
P31
P496
0000-0003-4109-1132