Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice. - Wikidata - awgldk - TriplyDB

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

http://www.wikidata.org/entity/Q33925312

about

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice.Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.Dystrophic Cardiomyopathy-Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy.Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.The potential of adeno-associated viral vectors for gene delivery to muscle tissue.Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1, -6, and -9 in neonatal dogs.A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy Experimental models of duchenne muscular dystrophy: relationship with cardiovascular disease.Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction.SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice AAV vectors for cardiac gene transfer: experimental tools and clinical opportunities.AAV-microdystrophin therapy improves cardiac performance in aged female mdx mice.Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy.Duchenne muscular dystrophy gene therapy in the canine model.Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs.Humoral immunity to AAV-6, 8, and 9 in normal and dystrophic dogs Analyzing cellular immunity to AAV in a canine model using ELISPOT assay Effect of nuclear factor κB inhibition on serotype 9 adeno-associated viral (AAV9) minidystrophin gene transfer to the mdx mouse.AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.Gene Therapy for Duchenne muscular dystrophy.Progress in gene therapy of dystrophic heart disease.Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy.100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy.Cardiac expression of a mini-dystrophin that normalizes skeletal muscle force only partially restores heart function in aged Mdx mice.An emerging adeno-associated viral vector pipeline for cardiac gene therapy Current Challenges and Future Directions in Recombinant AAV-Mediated Gene Therapy of Duchenne Muscular Dystrophy.Evaluation of vascular delivery methodologies to enhance rAAV6-mediated gene transfer to canine striated musculature.Gene therapy for muscular dystrophy: current progress and future prospects.Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy.Nanotherapy for Duchenne muscular dystrophy.Uniform low-level dystrophin expression in the heart partially preserved cardiac function in an aged mouse model of Duchenne cardiomyopathy.A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy.Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin.Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction.

P2860

Q24306601-92A58520-2F27-46B2-8635-340DF8AD8BA7 Q28082625-6796146F-B18C-42C1-B698-2727B43FA8FF Q28084979-FFC300B4-0690-44DA-A98E-30F472135D33 Q33494824-689BC991-2CD8-4368-AD8E-2485FB520399 Q33573648-7CD7F9F1-E6A0-4E68-AE9E-8E187A7B9E4F Q33608478-2D989003-9879-4E67-9E27-DDAFFB19F2AA Q33649295-6C409E20-4BB4-4B99-AA1F-64F4758594E9 Q33730464-4A3713BA-EF84-4E7C-8AE0-87F645DE5AD3 Q33902499-C03C1BA2-05D1-454C-8F25-4A174D86042A Q34001776-599886E6-7794-4432-B263-E779C87B4D26 Q34175938-CFF275D6-7919-421E-97A6-34B172E2DC4E Q34508301-DF484CC7-1BD6-40AF-B092-8B1050791ADD Q35027808-8AF7968F-FDF8-4AD8-9F8C-4AFC12F6F53B Q35086706-92B15DB8-0A27-49F1-A349-D48D56A48FA7 Q35183186-473AC5C5-8293-4CC2-99B4-0875F1F95F4F Q35238264-0222676C-BE33-4F07-9D03-8573264AFF66 Q35285784-42FEDF86-9F85-4BF8-B030-036377E45335 Q35540748-F0931E3C-AE58-4D27-B40A-7633AEE819DC Q35641673-19948C97-C3E6-4255-A807-3C86D167B7E0 Q35819142-399CBF01-C7E0-42B5-8546-F9C134750535 Q35823873-BCF9B63A-1AED-408E-8FF1-BD084DEAD028 Q35892390-D5EC1D8D-1937-4445-AAF3-65FE4BE4BB58 Q35973260-A05546C0-376F-4F98-AEB1-0185B112A296 Q36074749-799529A0-1C93-4369-872A-EEE2B11E2A45 Q36295934-43672679-2332-4CB1-9345-91A8B06C5DE0 Q36773242-D662D385-8BA2-47A9-8F83-AA8D4BBD81EB Q36966962-EA6302B3-C33B-4BD7-9D0C-106117EF5EDC Q37021623-CBA9CB86-54AA-43BE-B224-04F0B51A9E21 Q37069117-42DB2EEF-76CA-4B0F-9459-160947CC9571 Q37272277-A8E6C250-0F23-44BE-899B-887864BC18AB Q37272838-B53D0D06-E361-4B9C-B463-A50BAF3F438D Q37277411-108F1C69-2790-49B8-A3A6-5A8CFD849941 Q37460257-4A1EDDB1-B1B8-4C0B-AE4B-1BF53641EC0E Q37519650-A266E768-452E-48BC-A8FD-8556901CC3D8 Q38829627-8339170D-23FD-4345-B953-9A9DE3424121 Q39233936-961DFC5E-2FF6-43C1-8106-D34A9AD1B866 Q40445952-D75C042C-D504-42CF-9A7C-594A18C923B9 Q41171772-69AE79C9-353B-4041-A9DA-DB5820FC3B22 Q41919730-A8E3AEDF-75D2-414D-8841-BED235089C3B Q45868920-D9F2B0BB-13F8-4E8A-AEE8-ECDF756E447D

P2860

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

http://www.wikidata.org/entity/Q33925312

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@ast

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@en

type

label

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@ast

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@en

prefLabel

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@ast

Adeno-associated virus serotyp ...... hic abnormalities in mdx mice.

@en

P1433

Q33925312-1D5BE5DA-F58C-457D-9464-DE2361B2FE93

P1476

Q33925312-6E3FC8DE-5042-44C6-B644-ADD92774C7B1

P2093

Q33925312-3D2F914F-2C14-4FDE-AE72-EA538D152B12

Q33925312-85E6305C-7BB1-4F6D-B4DC-91AAFC981BFA

Q33925312-9DC96C3C-BA29-4EAD-A23F-1E1B4F36E51F

Q33925312-DB8D3D4F-0748-44AA-911F-54085133F193

P2860

Q33925312-0535ED73-4DE8-4766-8034-7E78F0FBC1D6

Q33925312-082CB4B1-53AC-4E52-BF47-F20A7AA0DAD4

Q33925312-0A6D3B5B-0B5B-4C70-A587-3D82D38C1CCC

Q33925312-0BBEFFE5-FD1F-49C3-B9DB-86BA27E2D33E

Q33925312-10F024E5-18EA-4A96-9F30-21A74B815E8E

Q33925312-12118DF0-87BA-4E32-90D7-F51956A09E90

Q33925312-1FA9A836-C305-44C7-9522-2C367E3CAA25

Q33925312-2906BD90-55CC-48D6-BD60-57FE2FB7FF99

Q33925312-2FA97161-5B94-47EA-9E3D-146271F9A5BE

Q33925312-3D0D3D9E-BCA7-49B4-83F7-4818CAD3DA1A

P304

Q33925312-9987E9AB-6D53-4F50-BB72-9273E3E1CFA8

P31

Q33925312-CA699A03-82FB-4C65-850D-0D42E73A95A5

P356

Q33925312-533B620E-83AB-43CC-BD5C-62E1415076A6

P433

Q33925312-F8CD50AC-ED85-491A-9439-B113878E42C4

P478

Q33925312-35056145-E383-4EBC-AC0F-B8E83CE9FE1C

P50

Q33925312-37D02F93-AF06-46B9-B6A5-2F14440B1D62

Q33925312-74325B5E-9FD5-4E4F-900E-C75139720C61

P577

Q33925312-123F3893-35ED-411A-80FC-AE0E0F9A58D4

P5875

Q33925312-C6F0FC30-EECD-4A20-8790-39A3B224123E

P698

Q33925312-01F79DD1-5426-4E38-8ACE-8C3B8D1D39D0

P921

Q33925312-1E653168-AEED-4FCB-A541-7A5ECD635EB9

Q33925312-3A3AF829-30F8-4AD6-B17D-C9E62AC60D8D

P932

Q33925312-65AADD84-4F6C-4C35-8DB0-20E6896EE140

P356

P1433

Human Gene Therapy

P1476

Adeno-associated virus serotyp ...... phic abnormalities in mdx mice

@en

P2093

Brian Bostick

http://www.w3.org/2001/XMLSchema#string

Chun Long

http://www.w3.org/2001/XMLSchema#string

Dejia Li

http://www.w3.org/2001/XMLSchema#string

Yongping Yue

http://www.w3.org/2001/XMLSchema#string

P2860

The syndrome of short P-R interval, normal QRS complex and paroxysmal rapid heart action

rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

2004 William Allan Award address. Cloning of the DMD gene.

Function and genetics of dystrophin and dystrophin-related proteins in muscle.

Clades of Adeno-associated viruses are widely disseminated in human tissues.

Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.

Adeno-associated viruses undergo substantial evolution in primates during natural infections.

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

The heart in muscular dystrophy.

P304

851-856

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1089/HUM.2008.058

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23137259

http://www.w3.org/2001/XMLSchema#string

P698

18666839

http://www.w3.org/2001/XMLSchema#string

P921

electrocardiography

P932

2888653

http://www.w3.org/2001/XMLSchema#string