A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.
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Ion Channels in the HeartCaMKII-dependent regulation of cardiac Na(+) homeostasisNa+ channel function, regulation, structure, trafficking and sequestrationCa(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequencesTargets for therapy in sarcomeric cardiomyopathiesFRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytesMechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the HeartIn silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.Electrophysiology and metabolism of caveolin-3-overexpressing mice.Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.Role of CaMKII in cardiac arrhythmias.Calcium signalling in developing cardiomyocytes: implications for model systems and disease.Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardiaEnhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets.Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus.Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytesAn integrative appraisal of mechano-electric feedback mechanisms in the heart.Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy.Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study.Simulation of the effects of moderate stimulation/inhibition of the β1-adrenergic signaling system and its components in mouse ventricular myocytes.Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.Mitochondrial Ca2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy.Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges
P2860
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P2860
A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
A novel computational model of ...... etween Na+ loading and CaMKII.
@en
A novel computational model of ...... etween Na+ loading and CaMKII.
@nl
type
label
A novel computational model of ...... etween Na+ loading and CaMKII.
@en
A novel computational model of ...... etween Na+ loading and CaMKII.
@nl
prefLabel
A novel computational model of ...... etween Na+ loading and CaMKII.
@en
A novel computational model of ...... etween Na+ loading and CaMKII.
@nl
P2860
P50
P1476
A novel computational model of ...... between Na+ loading and CaMKII
@en
P2093
A D McCulloch
A G Edwards
P2860
P304
P356
10.1113/JPHYSIOL.2013.266676
P407
P577
2014-01-13T00:00:00Z