Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells.
about
Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases.Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanismsElucidation of the roles of the Src kinases in pancreatic acinar cell signalingSrc Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium.Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in micePKCθ activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades.Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis.CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathwaysThe Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling moleculesPYK-2 is tyrosine phosphorylated after activation of pituitary adenylate cyclase activating polypeptide receptors in lung cancer cells.The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis eventsSrc kinases play a novel dual role in acute pancreatitis affecting severity but no role in stimulated enzyme secretionGastrointestinal growth factors and hormones have divergent effects on Akt activation.ANG II and LPA induce Pyk2 tyrosine phosphorylation in intestinal epithelial cells: role of Ca2+, PKC, and Rho kinase.Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells.Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini.CCK-8 inhibits expression of TNF-alpha in the spleen of endotoxic shock rats and signal transduction mechanism of p38 MAPK.Low affinity cholecystokinin receptor inhibits cholecystokinin- and bombesin-induced oscillations of cytosolic Ca2+ concentration.Changes in tyrosine phosphorylation associated with true capacitation and capacitation-like state in boar spermatozoa.
P2860
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P2860
Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@en
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@nl
type
label
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@en
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@nl
prefLabel
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@en
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@nl
P2093
P2860
P356
P1476
Cholecystokinin activates PYK2 ...... ay in pancreatic acinar cells.
@en
P2093
H A Ferris
L J García
R T Jensen
P2860
P304
31261-31271
P356
10.1074/JBC.274.44.31261
P407
P577
1999-10-01T00:00:00Z