Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.
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Identification of a chemical probe for NAADP by virtual screeningElimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shuntCritical role of gap junction coupled KATP channel activity for regulated insulin secretionGenome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biologyAltered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel.Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemiaMitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic isletsDysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutationsChronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cellsFoxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin releaseThe MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretionPancreatic beta cells require NeuroD to achieve and maintain functional maturityThe Role of Circulating Amino Acids in the Hypothalamic Regulation of Liver Glucose Metabolism.Brief suppression of Abcc8 prevents autodestruction of spinal cord after traumaPancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.Hyperinsulinism induced by targeted suppression of beta cell KATP channels.Why treatment fails in type 2 diabetesATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.Remote control of glucose homeostasis in vivo using photopharmacology.Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channelsATP-sensitive potassium channelopathies: focus on insulin secretionRegulation of insulin secretion: role of mitochondrial signalling.Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissuesMitochondrial signals in glucose-stimulated insulin secretion in the beta cell.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Genetic manipulation of insulin signaling, action and secretion in mice. Insights into glucose homeostasis and pathogenesis of type 2 diabetes.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Modeling K,ATP--dependent excitability in pancreatic islets.Uncoupling of secretion from growth in some hormone secretory tissues.K(ATP) channels and insulin secretion disorders.Diabetes and insulin secretion: whither KATP?The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1Muscle KATP channels: recent insights to energy sensing and myoprotectionPotassium channels in epithelial transport.
P2860
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P2860
Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Sur1 knockout mice. A model for K
@nl
Sur1 knockout mice. A model fo ...... gulation of insulin secretion.
@en
type
label
Sur1 knockout mice. A model for K
@nl
Sur1 knockout mice. A model fo ...... gulation of insulin secretion.
@en
prefLabel
Sur1 knockout mice. A model for K
@nl
Sur1 knockout mice. A model fo ...... gulation of insulin secretion.
@en
P2093
P356
P1476
Sur1 knockout mice. A model fo ...... gulation of insulin secretion.
@en
P2093
Aguilar-Bryan L
Nakazaki M
P304
P356
10.1074/JBC.275.13.9270
P407
P577
2000-03-01T00:00:00Z