The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action.
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Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulationDexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast.A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase.Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stressDistinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsMultiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatasesDual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.Active mutants of the human p38alpha mitogen-activated protein kinase.Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase.Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing.Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.Active ERK2 is sufficient to mediate growth arrest and differentiation signalingIsolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinasesMKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development.A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1.Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylationInduction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinaseLong-term dynamics of multisite phosphorylationSchnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function.Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma.Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors.New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest.Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations.Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphatase.DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Spatiotemporal regulation of ERK2 by dual specificity phosphatases.A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates.Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation.
P2860
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P2860
The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@en
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@nl
type
label
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@en
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@nl
prefLabel
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@en
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@nl
P2093
P2860
P1433
P1476
The sevenmaker gain-of-functio ...... pecificity phosphatase action.
@en
P2093
Marshall CJ
Thorneycroft SG
P2860
P304
P356
10.1016/0014-5793(94)00958-9
P407
P577
1994-09-01T00:00:00Z