Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling
about
Initiation of T cell signaling by CD45 segregation at 'close contacts'Aurora A drives early signalling and vesicle dynamics during T-cell activation.Phosphorylation site dynamics of early T-cell receptor signalingNovel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45In vitro membrane reconstitution of the T-cell receptor proximal signaling network.Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Small molecule inhibition of Csk alters affinity recognition by T cells.LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.An Emerging Role for PI5P in T Cell Biology.An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Insights into the initiation of TCR signaling.Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.PD-1 coinhibitory signals: the link between pathogenesis and protection.Aging, immunosenescence and membrane rafts: the lipid connectionIntegrative biology of T cell activation.Pharmacology of Src family kinases and therapeutic implications of their modulators.Intracellular signalling pathways: targets to reverse immunosenescence.Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.TCR signaling: the barrier within.Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderlyLck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of EngagementHow does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.Src-family kinases negatively regulate NFAT signaling in resting human T cells.Human c-SRC kinase (CSK) overexpression makes T cells dummy.Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.
P2860
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P2860
Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling
description
2011 nî lūn-bûn
@nan
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
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2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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2011年學術文章
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name
Feedback circuits monitor and ...... s in T cell receptor signaling
@en
Feedback circuits monitor and ...... s in T cell receptor signaling
@nl
type
label
Feedback circuits monitor and ...... s in T cell receptor signaling
@en
Feedback circuits monitor and ...... s in T cell receptor signaling
@nl
prefLabel
Feedback circuits monitor and ...... s in T cell receptor signaling
@en
Feedback circuits monitor and ...... s in T cell receptor signaling
@nl
P2093
P2860
P1433
P1476
Feedback circuits monitor and ...... s in T cell receptor signaling
@en
P2093
Chao Zhang
Jamie R Schoenborn
Kevan M Shokat
Ying Xim Tan
P2860
P356
10.1126/SCISIGNAL.2001893
P50
P577
2011-09-01T00:00:00Z