Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling.
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Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathwayCloning and characterization of human protease-activated receptor 4High-resolution crystal structure of human protease-activated receptor 1Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix sevenStructure prediction of the second extracellular loop in G-protein-coupled receptorsConstitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.Protease activated receptors: theme and variations.Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes.Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells.Peptide ligand recognition by G protein-coupled receptorsThe extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity.Progress in the understanding of protease-activated receptors.The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes.Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.Lifting the lid on GPCRs: the role of extracellular loops.Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function.Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor.Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits.Delineation of the structural basis for the activation properties of the dopamine D1 receptor subtypes.The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling.Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility.Pharmacological characterization of the constitutively activated state of the serotonin 5-HT2C receptor.Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.G protein-coupled receptors. I. Diversity of receptor-ligand interactions.The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors.Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.
P2860
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P2860
Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Thrombin receptor activating m ...... causes constitutive signaling.
@en
Thrombin receptor activating m ...... causes constitutive signaling.
@nl
type
label
Thrombin receptor activating m ...... causes constitutive signaling.
@en
Thrombin receptor activating m ...... causes constitutive signaling.
@nl
prefLabel
Thrombin receptor activating m ...... causes constitutive signaling.
@en
Thrombin receptor activating m ...... causes constitutive signaling.
@nl
P2093
P2860
P356
P1476
Thrombin receptor activating m ...... causes constitutive signaling.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.2.702
P407
P577
1996-01-01T00:00:00Z