about
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosisCrystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-βMutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human healthThe Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic VariantsVariation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax RelapsesmCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistancePlatinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes.In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions.Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity.DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein.Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration.pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.CSM-lig: a web server for assessing and comparing protein-small molecule affinities.Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel MutationsUbiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralisArpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein StructuresLst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.Flexibility and small pockets at protein-protein interfaces: New insights into druggability.Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.Structural approaches to probing metal interaction with proteins.Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance.SDM: a server for predicting effects of mutations on protein stability.Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab' Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity.Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma.PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins.Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design.Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David B Ascher
@ast
David B Ascher
@en
David B Ascher
@es
David B Ascher
@nl
David B Ascher
@sl
type
label
David B Ascher
@ast
David B Ascher
@en
David B Ascher
@es
David B Ascher
@nl
David B Ascher
@sl
prefLabel
David B Ascher
@ast
David B Ascher
@en
David B Ascher
@es
David B Ascher
@nl
David B Ascher
@sl
P106
P21
P2456
P31
P4012
P496
0000-0003-2948-2413