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Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorderGABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines.An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin miceThe neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistanceFunctional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cellsAltered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulationGABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadolAltered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunitPresynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala.Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin miceBehavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivationAltered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines.Production and characterization of murine models of classic and intermediate maple syrup urine diseaseNew insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout.Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardationAltered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout micePrototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder.Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in miceLoss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.Tonic for what ails us? high-affinity GABAA receptors and alcoholAttenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice.Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.Dual mechanism of brain injury and novel treatment strategy in maple syrup urine diseaseEthanol modulates synaptic and extrasynaptic GABAA receptors in the thalamusT-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors.
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P50
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Gregg E. Homanics
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0000-0003-3641-8153