Tonic for what ails us? high-affinity GABAA receptors and alcohol - Wikidata - awgldk - TriplyDB

Tonic for what ails us? high-affinity GABAA receptors and alcohol

Tonic for what ails us? high-affinity GABAA receptors and alcohol

http://www.wikidata.org/entity/Q36094683

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Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence.Synaptic effects induced by alcohol.Differential effects of acute alcohol on prepulse inhibition and event-related potentials in adolescent and adult Wistar rats Ethanol-BDNF interactions: still more questions than answers.Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder.Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.Habitual alcohol seeking: modeling the transition from casual drinking to addiction.The role of GABA(A) receptors in the development of alcoholism Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations.α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513.GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies Associations among types of impulsivity, substance use problems and neurexin-3 polymorphisms.Dihydromyricetin as a novel anti-alcohol intoxication medication.The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors.Ethanol's molecular targets Molecular genetics of alcohol dependence and related endophenotypes Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol.Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.Are Alcohol Anti-relapsing and Alcohol Withdrawal Drugs Useful in Cannabinoid Users?Synaptic targets: Chronic alcohol actions.Prevalence and clinical correlates of flunitrazepam-related complex sleep behaviors.Effects of Ethanol on Cellular Composition and Network Excitability of Human Pluripotent Stem Cell-Derived Neurons.Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.Ethanol selectively attenuates NMDAR-mediated synaptic transmission in the prefrontal cortex.The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.α2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus.The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.Allosteric Modulation of αβδ GABAA Receptors.Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol Effects in Vivo.GABAA receptor: Positive and negative allosteric modulators.

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P2860

Tonic for what ails us? high-affinity GABAA receptors and alcohol

http://www.wikidata.org/entity/Q36094683

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2007 nî lūn-bûn

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J.ALCOHOL.2007.03.008

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David M Lovinger

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P2860

Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513

Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors

The benzodiazepine receptor inverse agonist RO15-4513 exacerbates, but does not precipitate, ethanol withdrawal in mice

Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit

Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

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139-143

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scholarly article

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10.1016/J.ALCOHOL.2007.03.008

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3

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41

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Gregg E. Homanics

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2007-05-23T00:00:00Z

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6310663

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2043151

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