Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase - Wikidata - awgldk - TriplyDB

Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase

Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase

http://www.wikidata.org/entity/Q42575382

about

The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration Structural basis for the recognition of Asef by adenomatous polyposis coli.Asef controls vascular endothelial permeability and barrier recovery in the lung.Hepatocyte growth factor-induced Asef-IQGAP1 complex controls cytoskeletal remodeling and endothelial barrier.The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.APC selectively mediates response to chemotherapeutic agents in breast cancer.Mechanisms of RAS/β-catenin interactions.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.Differences in the localization of the adenomatous polyposis coli-Asef/Asef2 complex between adenomatous polyposis coli wild-type and mutant cells.The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.Molecular spectrum of secretome regulates the relative hepatogenic potential of mesenchymal stem cells from bone marrow and dental tissue.

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Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase

http://www.wikidata.org/entity/Q42575382

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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name

Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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type

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

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JBC.M109.020768

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Journal of Biological Chemistry

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Adenomatous polyposis coli and ...... phosphatidylinositol 3-kinase

@en

P2093

Kanae Echizen

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Masaki Sagara

http://www.w3.org/2001/XMLSchema#string

Shinnosuke Tsuji

http://www.w3.org/2001/XMLSchema#string

Tetsu Akiyama

http://www.w3.org/2001/XMLSchema#string

Yoko Shibata

http://www.w3.org/2001/XMLSchema#string

Yoshihiro Kawasaki

http://www.w3.org/2001/XMLSchema#string

P2860

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

Asef, a link between the tumor suppressor APC and G-protein signaling

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element

An integrated genomic analysis of human glioblastoma multiforme

Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

The phosphoinositide 3-kinase pathway

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22436-22443

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scholarly article

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10.1074/JBC.M109.020768

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33

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284

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19525225

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2755965

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