Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element
about
The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)miceAsef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migrationThe Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migrationEpithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionCdc42 in oncogenic transformation, invasion, and tumorigenesisStructural basis for the recognition of Asef by adenomatous polyposis coli.The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagenPhosphorylation of serine 106 in Asef2 regulates cell migration and adhesion turnover.Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups.Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus.The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdalaThe miR-1-NOTCH3-Asef pathway is important for colorectal tumor cell migrationI'm coming to GEF you: Regulation of RhoGEFs during cell migration.ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome.CDC42 inhibition suppresses progression of incipient intestinal tumors.Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration.Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinaseTCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region.The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region
P2860
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P2860
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@ast
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en-gb
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@nl
type
label
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@ast
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en-gb
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@nl
prefLabel
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@ast
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en-gb
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@nl
P2093
P2860
P921
P356
P1476
Asef2 functions as a Cdc42 exc ...... C-terminal activation element
@en
P2093
Casey M Lubking
Daniel D Billadeau
Doris N Luchini
Michael J Hamann
P2860
P304
P356
10.1128/MCB.01608-06
P407
P577
2007-02-01T00:00:00Z