Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
about
Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migrationCrystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domainThe F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesisRegulation of small GTPases by GEFs, GAPs, and GDIsStructural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2A conformational switch in collybistin determines the differentiation of inhibitory postsynapsesRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerSpecificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS.The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.Structural basis for the recognition of Asef by adenomatous polyposis coli.The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteinsOn the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Novel association of APC with intermediate filaments identified using a new versatile APC antibodyRho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localizationIntermolecular steric inhibition of Ephexin4 is relieved by Elmo1.Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways.Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effectorStructures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners.Allosteric properties of PH domains in Arf regulatory proteins.Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.Rho GTPase signaling in the development of colorectal cancer.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.CDC42 inhibition suppresses progression of incipient intestinal tumors.Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalARegulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinaseMechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis.Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
P2860
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P2860
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@ast
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@en
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@nl
type
label
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@ast
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@en
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@nl
prefLabel
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@ast
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@en
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@nl
P2093
P2860
P921
P356
P1476
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
@en
P2093
Channing J Der
Kent L Rossman
Laurie Betts
Marielle E Yohe
Natalia Mitin
P2860
P2888
P304
P356
10.1038/NSMB1290
P50
P577
2007-09-01T00:00:00Z
P5875
P6179
1004246377