An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor.
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Epibatidine activates muscle acetylcholine receptors with unique site selectivity.Effects of serotonergic agents on neuronal nicotinic acetylcholine receptorsEnd-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseFive ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine responseStructural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptorInside-out neuropharmacology of nicotinic drugsStructures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopyStructural basis of open channel block in a prokaryotic pentameric ligand-gated ion channelMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Neuronal nicotinic receptors: from protein structure to functionThe atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channelsDiltiazem causes open channel block of recombinant 5-HT3 receptorsTryptophan substitutions at lipid-exposed positions of the gamma M3 transmembrane domain increase the macroscopic ionic current response of the Torpedo californica nicotinic acetylcholine receptorPregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunitCyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channelsMapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonistMolecular dynamics simulations of water within models of ion channels.Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function.The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor.Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutationsA neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegansThe noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor poreChannel blocking properties of a series of nicotinic cholinergic agonists.Threonine in the selectivity filter of the acetylcholine receptor channel.Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism.Pore conformations and gating mechanism of a Cys-loop receptor.Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor.Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility methodStructural effects of quinacrine binding in the open channel of the acetylcholine receptor.The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain.The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells.Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction.Diverse inhibitory actions of quaternary ammonium cholinesterase inhibitors on Torpedo nicotinic ACh receptors transplanted to Xenopus oocytes.Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action.Voltage-jump relaxation kinetics for wild-type and chimeric beta subunits of neuronal nicotinic receptorsMechanisms of barbiturate inhibition of acetylcholine receptor channels
P2860
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P2860
An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
An open-channel blocker intera ...... otinic acetylcholine receptor.
@en
An open-channel blocker intera ...... otinic acetylcholine receptor.
@nl
type
label
An open-channel blocker intera ...... otinic acetylcholine receptor.
@en
An open-channel blocker intera ...... otinic acetylcholine receptor.
@nl
prefLabel
An open-channel blocker intera ...... otinic acetylcholine receptor.
@en
An open-channel blocker intera ...... otinic acetylcholine receptor.
@nl
P2093
P1433
P1476
An open-channel blocker intera ...... otinic acetylcholine receptor.
@en
P2093
Davidson N
Leonard RJ
Vogelaar NJ
P356
10.1016/0896-6273(90)90445-L
P407
P577
1990-01-01T00:00:00Z