Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.
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Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partnerHomotropic allosteric regulation in monomeric mammalian glucokinaseConformational transition pathway in the activation process of allosteric glucokinaseThe active conformation of human glucokinase is not altered by allosteric activatorsInsights into Mechanism of Glucokinase ActivationEssential role of conformational selection in ligand bindingMolecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic TriadHow to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation RatesA phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activatorsAnalysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescenceThermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and ureaGlobal fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinaseOrder-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinaseIdentification of two-step chemical mechanisms using small temperature oscillations and a single tagged species.Conformational selection or induced fit? A critical appraisal of the kinetic mechanism.Solution NMR Spectroscopy for the Study of Enzyme Allostery.Small-Molecule Allosteric Activation of Human Glucokinase in the Absence of Glucose.Mutational analysis of allosteric activation and inhibition of glucokinase.Protein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework.An integrated perspective on RNA aptamer ligand-recognition models: clearing muddy waters.A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation.Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM.Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent.Binding of ATP at the active site of human pancreatic glucokinase--nucleotide-induced conformational changes with possible implications for its kinetic cooperativity.Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.Induced Fit Is a Special Case of Conformational Selection.Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels.
P2860
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P2860
Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Binding kinetics of glucose an ...... ultiple conformational states.
@en
Binding kinetics of glucose an ...... ultiple conformational states.
@nl
type
label
Binding kinetics of glucose an ...... ultiple conformational states.
@en
Binding kinetics of glucose an ...... ultiple conformational states.
@nl
prefLabel
Binding kinetics of glucose an ...... ultiple conformational states.
@en
Binding kinetics of glucose an ...... ultiple conformational states.
@nl
P356
P1433
P1476
Binding kinetics of glucose an ...... multiple conformational states
@en
P2093
Gilles Ferry
Mathias Antoine
P304
P356
10.1021/BI900374C
P407
P577
2009-06-01T00:00:00Z