The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.
about
A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cellsProgranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domainsThe growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcriptionThe zebrafish progranulin gene family and antisense transcripts.Mechanisms of granulin deficiency: lessons from cellular and animal modelsPotential mechanisms of progranulin-deficient FTLDA 30-residue fragment of the carp granulin-1 protein folds into a stack of two beta-hairpins similar to that found in the native proteinStructure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activitiesRedox and Light Control the Heme-Sensing Activity of AppAProgranulin: normal function and role in neurodegenerationA slow maturation of a cysteine protease with a granulin domain in the vacuoles of senescing Arabidopsis leavesCartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferationThe Evolution of the Secreted Regulatory Protein ProgranulinRecent insights into the molecular genetics of dementiaGranulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.The Opisthorchis viverrini genome provides insights into life in the bile ductUpregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndromeGranulin exacerbates lupus nephritis via enhancing macrophage M2b polarization.Progranulin expression is upregulated after spinal contusion in mice.The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.Progranulin: a promising therapeutic target for rheumatoid arthritis.Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity.The role of PGRN in musculoskeletal development and disease.Progranulin: a growth factor, a novel TNFR ligand and a drug targetPrevention of LPS-induced acute lung injury in mice by progranulinProgranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Insights into the role of progranulin in immunity, infection, and inflammation.Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamicsExpression level of the growth factor progranulin is related with development of systemic lupus erythematosus.Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice.Role of progranulin as a biomarker for Alzheimer's disease.Cellular effects of progranulin in health and disease.Structure, function, and mechanism of progranulin; the brain and beyond.Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.
P2860
Q21131573-58A750D3-805C-4B5D-A262-955B0D4673E4Q24337327-1A560592-29D6-4303-8697-036DDAF933D0Q24554329-72FB7D21-0CB6-45E6-922F-5358EED32EC6Q24816085-83E43615-6633-4326-80E8-EBACEAF16848Q26824221-0758D5A8-BEA4-480C-997F-89EEB30D13E4Q26863702-AD77A14E-89CD-4004-8100-C2E53F27D981Q27619158-7964E281-935E-48DA-8BE1-3A9E68A45118Q27650138-045D05FA-8F72-4B9C-A326-9553D327C9CBQ27679815-CF30EA88-9705-4BEE-BF96-0A0866DCE3FDQ28254281-89B107E9-1858-476D-BFB5-0AD9DCD52DA7Q28366385-DE135FEF-8EA5-4A98-BAA7-71823E12A1B2Q28569341-5D483FAA-53E7-465F-8288-0E130FB190AFQ28642185-613BA3BC-F4AA-415B-80CA-6D2D04D8D3A2Q33830518-D09CEF21-A8DD-408B-9B76-2E8DADF977C3Q33868752-3B5FE64F-A59A-4A1D-8682-9B6A1E7AD66EQ33924064-9ABDEEEE-9E83-4309-93E3-E6E848477D47Q34292351-9D4D6A85-200B-4AEB-82AA-1EF953416B22Q34766619-CF60EA49-668A-4BBF-9048-7EC553368269Q34916082-9A42C373-E314-4922-BA48-ACE37B7DC774Q35014661-15A5E63C-D3EC-474C-8CD1-B87E614F9DB5Q35126225-C580592D-5360-4D66-A459-09BBB87988B1Q35182029-1E4B9A4E-8A2B-4F7B-AA87-C4C946F30280Q35541825-F13C1FE6-481D-4A17-AEAF-00150E75BDFBQ35546476-D9A46828-8074-4161-ABE7-358223594F2CQ35601050-D5899698-1DD5-4A05-9D85-4D9C6612DC31Q36200118-F235FD6E-CB85-458F-A623-994ACB251AC1Q36294670-4A7861B1-CFF5-4EB0-A60D-0BE319A4A26BQ36534831-D6494268-5467-42D6-B572-6E4564BF8CDBQ36583034-D813E685-0881-47F1-B7BA-E716CE0F960EQ36595272-D78FBCB8-5E66-44B4-930D-64FFCCFD4003Q36794765-807807C3-BFCB-4A67-A68B-4993749BE22BQ36922255-1CE79DB7-80A4-4530-A8C1-55C2904F3D83Q37294604-6C1D938C-BD7F-4505-866E-3CABA5B72D00Q37359314-F7C19350-F0EF-4D5A-BB23-A2593BB2CC04Q37604580-81D7F416-3C67-4011-B2E3-1362AB579B83Q37704536-4BB33B8F-BD0F-4C14-B93C-77E1E9754F43Q37730008-F4FB3FA3-E446-4678-A4F0-C81EDFB1A434Q37879596-CFBC8895-BDAB-4D05-A008-DB1A61730A4FQ37892442-68CDB3B6-A276-449D-A24E-0B19CAEAB69BQ38219206-C0CB4C50-27CD-4F36-B8ED-182D846F3CEF
P2860
The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
The hairpin stack fold, a nove ...... ily of protein growth factors.
@en
The hairpin stack fold, a nove ...... ily of protein growth factors.
@nl
type
label
The hairpin stack fold, a nove ...... ily of protein growth factors.
@en
The hairpin stack fold, a nove ...... ily of protein growth factors.
@nl
prefLabel
The hairpin stack fold, a nove ...... ily of protein growth factors.
@en
The hairpin stack fold, a nove ...... ily of protein growth factors.
@nl
P2093
P2860
P356
P1476
The hairpin stack fold, a nove ...... ily of protein growth factors.
@en
P2093
P2860
P304
P356
10.1038/NSB0996-747
P577
1996-09-01T00:00:00Z