A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr
about
Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activationShared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptideIdentification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptoIdentification of a gp130 cytokine receptor critical site involved in oncostatin M response.High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex.Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cells.IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.New approaches in the treatment of asthma.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.Intracellular signal transduction in eosinophils and its clinical significance.Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy.Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction.Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognitionAn improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.Interleukin-5 receptor subunit oligomerization and rearrangement revealed by fluorescence resonance energy transfer imagingSlow-dissociation effect of common signaling subunit beta c on IL5 and GM-CSF receptor assembly.Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptorsThe granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice.The GM-CSF receptor family: mechanism of activation and implications for disease.CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies.{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains.Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.LIF receptor-gp130 interaction investigated by homology modeling: implications for LIF binding.DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms.Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly.Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils.Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.CD123 immunostaining patterns in systemic mastocytosis: differential expression in disease subgroups and potential prognostic value.Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells.
P2860
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P2860
A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
A single tyrosine residue in t ...... nding and signaling by all thr
@en
A single tyrosine residue in t ...... nding and signaling by all thr
@nl
type
label
A single tyrosine residue in t ...... nding and signaling by all thr
@en
A single tyrosine residue in t ...... nding and signaling by all thr
@nl
prefLabel
A single tyrosine residue in t ...... nding and signaling by all thr
@en
A single tyrosine residue in t ...... nding and signaling by all thr
@nl
P2860
P356
P1476
A single tyrosine residue in t ...... signaling by all three ligands
@en
P2093
B Zacharakis
C J Bagley
P2860
P304
25999-26006
P356
10.1074/JBC.271.42.25999
P407
P577
1996-10-01T00:00:00Z