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Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machineryImmunotherapy targeting pyroglutamate-3 Aβ: prospects and challengesA quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues.Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug developmentInhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegenerationIntraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelPyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanismsIsoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse modelsInhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
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description
hulumtues
@sq
researcher
@en
wetenschapper
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հետազոտող
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name
Holger Cynis
@ast
Holger Cynis
@en
Holger Cynis
@es
Holger Cynis
@nl
Holger Cynis
@sl
type
label
Holger Cynis
@ast
Holger Cynis
@en
Holger Cynis
@es
Holger Cynis
@nl
Holger Cynis
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prefLabel
Holger Cynis
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Holger Cynis
@en
Holger Cynis
@es
Holger Cynis
@nl
Holger Cynis
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P106
P21
P31
P496
0000-0001-6655-7539