Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.
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P2X receptors as targets for the treatment of status epilepticusRole of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation "in vivo" by P2X7 receptorCritical Evaluation of P2X7 Receptor Antagonists in Selected Seizure ModelsBmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injuryNeurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional rolesTransgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.ATP as a multi-target danger signal in the brain.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects.L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade.Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.Adenosine A2A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE).Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation.Role of purinergic signaling in experimental pneumococcal meningitisP2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.Neurotransmitter signaling in the pathophysiology of microglia.P2X and P2Y receptors—role in the pathophysiology of the nervous system.Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy.P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells.The microglial ATP-gated ion channel P2X7 as a CNS drug target.The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant EpilepsyRole of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine.Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in miceInhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus.Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in MiceIncreased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079.Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1 receptors in naive and chronic epileptic rats.Inhibition of P2X7 Receptor Ameliorates Nuclear Factor-Kappa B Mediated Neuroinflammation Induced by Status Epilepticus in Rat Hippocampus.Pirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus.Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex.Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus.Subsequent Bilateral Hippocampal Diffusion Restriction and Atrophy in Repeated Status Epilepticus.Increased Expression and Cellular Localization of P2X7R in Cortical Lesions of Patients With Focal Cortical Dysplasia.Role of P2X7 purinoceptors in neuroprotective mechanism of ischemic postconditioning in mice.Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy.The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy.
P2860
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P2860
Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Seizure suppression and neurop ...... ng status epilepticus in mice.
@en
Seizure suppression and neurop ...... ng status epilepticus in mice.
@nl
type
label
Seizure suppression and neurop ...... ng status epilepticus in mice.
@en
Seizure suppression and neurop ...... ng status epilepticus in mice.
@nl
prefLabel
Seizure suppression and neurop ...... ng status epilepticus in mice.
@en
Seizure suppression and neurop ...... ng status epilepticus in mice.
@nl
P2093
P50
P356
P1433
P1476
Seizure suppression and neurop ...... ing status epilepticus in mice
@en
P2093
Amaya Sanz-Rodriguez
Guillaume Mesuret
Katsuhiro Tanaka
Paula Garcia-Huerta
P304
P356
10.1096/FJ.11-196089
P407
P50
P577
2011-12-23T00:00:00Z