Structural basis for selectivity and toxicity of ribosomal antibiotics. - Wikidata - awgldk - TriplyDB

Structural basis for selectivity and toxicity of ribosomal antibiotics.

Structural basis for selectivity and toxicity of ribosomal antibiotics.

http://www.wikidata.org/entity/Q42724085

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Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones New developments in aminoglycoside therapy and ototoxicity Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action The Impact of Aminoglycosides on the Dynamics of Translation Elongation Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin 4′-O-substitutions determine selectivity of aminoglycoside antibiotics Targeting Antibiotic Resistance Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines Identification of ribosomal proteins specific to higher eukaryotic organisms Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.Aminoglycoside activity observed on single pre-translocation ribosome complexes.Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations Molecular mechanisms by which rRNA mutations confer resistance to clindamycin 23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.5 S rRNA: structure and interactions.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Inhibition of protein synthesis by aminoglycoside-arginine conjugates.Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B RNA as a drug target: the case of aminoglycosides.Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity.Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups Antibiotics and the ribosome.Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae.Mitochondrial deafness alleles confer misreading of the genetic code Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases.Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux RNA-based therapeutic approaches for coagulation factor deficiencies.Elements of ribosomal drug resistance and specificity.Phylogenetic sequence variations in bacterial rRNA affect species-specific susceptibility to drugs targeting protein synthesis.Mitochondrial antibiograms in personalized medicine.The macrolide antibiotic renaissance.

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P2860

Structural basis for selectivity and toxicity of ribosomal antibiotics.

http://www.wikidata.org/entity/Q42724085

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2001年论文

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name

Structural basis for selectivity and toxicity of ribosomal antibiotics.

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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type

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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Structural basis for selectivity and toxicity of ribosomal antibiotics.

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B Springer

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P2860

Basis for prokaryotic specificity of action of aminoglycoside antibiotics.

The structural basis of ribosome activity in peptide bond synthesis

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic

Interaction of antibiotics with functional sites in 16S ribosomal RNA

Aminoglycosides: nephrotoxicity

E. coli ribosomes with a C912 to U base change in the 16S rRNA are streptomycin resistant.

Antibiotic resistance mutations in the chloroplast 16S and 23S rRNA genes of Chlamydomonas reinhardtii: correlation of genetic and physical maps of the chloroplast genome

Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.

Ribosomal RNA and translation.

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