Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
about
Physical dissociation of the TCR-CD3 complex accompanies receptor ligationCD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Epitope mapping by photobleaching fluorescence resonance energy transfer measurements using a laser scanning microscope systemAdapter molecules in T cell receptor signaling.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor.Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson modelSome hints concerning the shape of T-cell receptor structures.Structural hierarchy in the clustering of HLA class I molecules in the plasma membrane of human lymphoblastoid cells.Multivalent structure of an alphabetaT cell receptor.Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulumSingle-molecule level analysis of the subunit composition of the T cell receptor on live T cellsDifferential depletion of total T cells and regulatory T cells and prolonged allotransplant survival in CD3Ɛ humanized mice treated with polyclonal anti human thymocyte globulin.Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytesCoexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Superantigen staphylococcal enterotoxin B-induced T-helper cell activation is independent of CD4 molecules and phosphatidylinositol hydrolysis.Characterization of a surrogate murine antibody to model anti-human CD3 therapies.T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouseSurface expression of alternative forms of the TCR/CD3 complex.Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.Antigen receptors on T and B lymphocytes: parallels in organization and function.Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum.Hierarchy of T cell antigen receptor assembly.Distinct domains of the CD3-gamma chain are involved in surface expression and function of the T cell antigen receptor.Structure of the T-cell receptor in a Ti alpha beta, Ti gamma delta double positive T-cell line.Defective expression and tyrosine phosphorylation of the T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients.A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.Biochemical evidence for the presence of a single CD3delta and CD3gamma chain in the surface T cell receptor/CD3 complex.Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus.
P2860
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P2860
Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Structure of the T cell antige ...... n a functional TCR/CD3 complex
@en
Structure of the T cell antigen receptor
@nl
type
label
Structure of the T cell antige ...... n a functional TCR/CD3 complex
@en
Structure of the T cell antigen receptor
@nl
prefLabel
Structure of the T cell antige ...... n a functional TCR/CD3 complex
@en
Structure of the T cell antigen receptor
@nl
P2093
P2860
P356
P1476
Structure of the T cell antige ...... n a functional TCR/CD3 complex
@en
P2093
P2860
P356
10.1084/JEM.173.1.7
P407
P577
1991-01-01T00:00:00Z