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T cell receptor gene therapy for cancerLinking form to function: Biophysical aspects of artificial antigen presenting cell designStructure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1CD3 delta establishes a functional link between the T cell receptor and CD8Evidence for a functional sidedness to the alphabetaTCR.Conserved transmembrane tyrosine residues of the TCR beta chain are required for TCR expression and function in primary T cells and hybridomas.T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.The organizing principle in the formation of the T cell receptor-CD3 complex.Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors.T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model.Organization of the resting TCR in nanoscale oligomers.Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.Initiation of TCR signaling: regulation within CD3 dimers.A variable immunoreceptor in a subpopulation of human neutrophils.A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell.Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRsTCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.Molecular mechanisms for the assembly of the T cell receptor-CD3 complex.Facilitating matched pairing and expression of TCR chains introduced into human T cells.Single-molecule level analysis of the subunit composition of the T cell receptor on live T cellsAnergy induction by dimeric TCR ligandsStoichiometry of the murine gammadelta T cell receptorCoexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Signaling defects in anti-tumor T cellsSelective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles.Visualization of protein interactions in living cells.T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.Pre-clustered TCR complexes.TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.Receptor Dissociation and B-Cell Activation.The Allostery Model of TCR Regulation.Early T-cell activation biophysics.Peptide-MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices.CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers.Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Multivalent structure of an alphabetaT cell receptor.
@ast
Multivalent structure of an alphabetaT cell receptor.
@en
type
label
Multivalent structure of an alphabetaT cell receptor.
@ast
Multivalent structure of an alphabetaT cell receptor.
@en
prefLabel
Multivalent structure of an alphabetaT cell receptor.
@ast
Multivalent structure of an alphabetaT cell receptor.
@en
P2093
P2860
P356
P1476
Multivalent structure of an alphabetaT cell receptor.
@en
P2093
A Iglesias
A de la Hera
G Fernández-Miguel
H Bluethmann
M Alvarez-Mon
P2860
P304
P356
10.1073/PNAS.96.4.1547
P407
P577
1999-02-01T00:00:00Z