Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
about
Protein kinases and phosphatases in the control of cell fateInsights into APC/C: from cellular function to diseases and therapeuticsContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisTargeting the Mitotic Catastrophe Signaling Pathway in CancerThe overlooked greatwall: a new perspective on mitotic controlPP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activationFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisThe 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsGlobal Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation MotifsA first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructThe Basic Biology of PP2A in Hematologic Cells and MalignanciesProtein phosphatase 1 is essential for Greatwall inactivation at mitotic exitLATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progressionPP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.Microtubule-dependent regulation of mitotic protein degradation.Kinetic framework of spindle assembly checkpoint signallingSynergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.Cdc20: a potential novel therapeutic target for cancer treatmentProtein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progressionα-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytesAPC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistancePhosphatase 1 nuclear targeting subunit is an essential regulator of M-phase entry, maintenance, and exitInhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.Cohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestThe tumor suppressor CDKN3 controls mitosis.PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.The biochemistry of mitosisMASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.Targeting Cdc20 as a novel cancer therapeutic strategy.Killing cells by targeting mitosisA CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.Protein phosphatases and their regulation in the control of mitosisThe APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisPP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer
P2860
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P2860
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@en
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@nl
type
label
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@en
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@nl
prefLabel
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@en
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@nl
P2093
P50
P1433
P1476
Targeting mitotic exit leads t ...... d the PP2A/B55α,δ phosphatase.
@en
P2093
Eusebio Manchado
Hiroyuki Yamano
Irene García-Higuera
Marta Cañamero
María Guillamot
Michelle Trickey
Sergio Moreno
P304
P356
10.1016/J.CCR.2010.10.028
P577
2010-12-01T00:00:00Z