about
The ceramide-activated protein phosphatase Sit4p controls lifespan, mitochondrial function and cell cycle progression by regulating hexokinase 2 phosphorylation.Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases.Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathwayModulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasitesThe yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids.Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism.Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.Effect of myricetin, pyrogallol, and phloroglucinol on yeast resistance to oxidative stress.Accumulation of non-superoxide anion reactive oxygen species mediates nitrogen-limited alcoholic fermentation by Saccharomyces cerevisiae.Cellular models of aging.Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7.The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae.Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells.Yeast as a platform to uncover ceramide-induced ancient cell death routines.Guidelines and recommendations on yeast cell death nomenclature.Using yeast to uncover the regulation of protein kinase Cδ by ceramide.The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation.A yeast model of the Parkinson's disease-associated protein Parkin.Production of orotic acid by a Klura3Δ mutant of Kluyveromyces lactis.Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.Effect of diflubenzuron on the development of Pinus pinaster seedlings inoculated with the ectomycorrhizal fungus Pisolithus tinctorius.Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria.Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase.Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells.Acquisition of ethanol tolerance in Saccharomyces cerevisiae: the key role of the mitochondrial superoxide dismutase.Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.Heme as a source of iron to Leishmania infantum amastigotesThe Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiaeQuercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiaeRequirement of glutathione for Sod1 activation during lifespan extensionPkh1p-Ypk1p and Pkh1p-Sch9p Pathways Are Activated by Acetic Acid to Induce a Mitochondrial-Dependent Regulated Cell DeathActivation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Vítor Costa
@ast
Vítor Costa
@en
Vítor Costa
@es
Vítor Costa
@nl
Vítor Costa
@sl
type
label
Vítor Costa
@ast
Vítor Costa
@en
Vítor Costa
@es
Vítor Costa
@nl
Vítor Costa
@sl
altLabel
Vítor MV Costa
@en
prefLabel
Vítor Costa
@ast
Vítor Costa
@en
Vítor Costa
@es
Vítor Costa
@nl
Vítor Costa
@sl
P1053
A-2647-2008
P106
P1153
7103026233
P21
P31
P3829
P496
0000-0002-7868-4663