Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion. - Wikidata - awgldk - TriplyDB

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion.

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion.

http://www.wikidata.org/entity/Q42803797

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Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis Regulation of Xenopus gastrulation by ErbB signaling.Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling Integrin-blocking antibodies delay keratinocyte re-epithelialization in a human three-dimensional wound healing model Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation.Dynamics of the alpha6beta4 integrin in keratinocytes.Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation.The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis.miR-221/222 control luminal breast cancer tumor progression by regulating different targets.Phosphatidylinositol 3-kinases in tumor progression.Androgen receptor and prostate cancer invasion.Biologic and therapeutic role of HER2 in cancer.Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis Mechanisms of tumour invasion and metastasis: emerging targets for therapy.Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling.Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.Involvement of alpha6beta4 integrin in the mechanisms that regulate breast cancer progression.Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression.Netrin-4 promotes glioblastoma cell proliferation through integrin β4 signaling Clinical significance of the integrin α6β4 in human malignancies.Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.Palmitoylation supports assembly and function of integrin-tetraspanin complexes Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin.Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination.Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression.Role of ErbB2 in Corneal Epithelial Wound Healing.The role of Neuregulin-1beta/ErbB signaling in the heart.

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P2860

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion.

http://www.wikidata.org/entity/Q42803797

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2000 nî lūn-bûn

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Cooperative signaling between alpha

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Cooperative signaling between ...... l 3-kinase-dependent invasion.

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Cooperative signaling between alpha

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Cooperative signaling between ...... l 3-kinase-dependent invasion.

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Cooperative signaling between alpha

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Cooperative signaling between ...... l 3-kinase-dependent invasion.

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JBC.275.14.10604

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Journal of Biological Chemistry

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Benedetti L

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Falcioni R

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Gambaletta D

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Marchetti A

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Mercurio AM

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Sacchi A

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P2860

The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures

Laminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrins

Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.

The integrin alpha 6 beta 4 is a laminin receptor.

Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve.

VLA proteins in the integrin family: structures, functions, and their role on leukocytes.

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10604-10610

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10744756

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