Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis.
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A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteinsThe tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosisMolecular genetics of neurofibromatosis type 1 (NF1)Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesisInactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.RasSorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cellsC-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzymeIdentification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras allelesLeukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding proteinEffect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and RasMouse models of neurofibromatosis 1 and 2.Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patientsMolecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCREliminating barriers to personalized medicine: learning from neurofibromatosis type 1Tumors of the neural crest: Common themes in development and cancerMAPK pathway activation in pilocytic astrocytomaActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsMxi1 mutations in human neurofibrosarcomasNeurofibromatosis type 1 - a model for nervous system tumour formation?PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cellsNf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemiaAblation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesThe neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 miceRole of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cellsThe neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 miceNf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferaseOncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosisThe Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblastsTumour predisposition in mice heterozygous for a targeted mutation in Nf1In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeSubependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosisReduced expression of neurofibromin in human meningiomasEpidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal modelsLovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1.Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.Plexiform neurofibromas.Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma.Malignant Peripheral Nerve Sheath Tumors State of the Science: Leveraging Clinical and Biological Insights into Effective Therapies.
P2860
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P2860
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Abnormal regulation of mammali ...... en (type 1) neurofibromatosis.
@en
Abnormal regulation of mammali ...... r growth in von Recklinghausen
@nl
type
label
Abnormal regulation of mammali ...... en (type 1) neurofibromatosis.
@en
Abnormal regulation of mammali ...... r growth in von Recklinghausen
@nl
prefLabel
Abnormal regulation of mammali ...... en (type 1) neurofibromatosis.
@en
Abnormal regulation of mammali ...... r growth in von Recklinghausen
@nl
P2093
P4510
P1433
P1476
Abnormal regulation of mammali ...... en (type 1) neurofibromatosis.
@en
P2093
Fletcher JA
Papageorge AG
P304
P356
10.1016/0092-8674(92)90407-4
P407
P577
1992-04-01T00:00:00Z