Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
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Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor ActivationPredicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysisHepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverMechanisms of hepatic fibrogenesisActivation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cellsThe protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid.The PXR is a drug target for chronic inflammatory liver disease.Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes.Targeting the pregnane X receptor in liver injury.Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cellsMRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors.Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degenerationFocus on therapeutic strategies of nonalcoholic Fatty liver diseaseProgenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.Nuclear receptors as drug targets in cholestatic liver diseases.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studiesEnvironmental Xenoestrogens Super-Activate a Variant Murine ER Beta in Cholangiocytes.Fibrogenesis in nonalcoholic steatohepatitis.Pregnane X receptor polymorphisms associated with human diseases.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.The stellate cell system (vitamin A-storing cell system).Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.Expression of CYP2S1 in human hepatic stellate cells.Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture systemIdentification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis
P2860
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P2860
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.
@en
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR
@nl
type
label
Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.
@en
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR
@nl
prefLabel
Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.
@en
Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR
@nl
P2093
P2860
P356
P1433
P1476
Pregnenolone-16alpha-carbonitr ...... and PXR-independent mechanisms
@en
P2093
Bryan Goodwin
Carylyn J Marek
Dee Haefner
Dimitrios K Konstantinou
Graeme I Murray
Lucy J Elrick
Steven J Tucker
P2860
P304
P356
10.1042/BJ20041598
P407
P577
2005-05-01T00:00:00Z