Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. - Wikidata - awgldk - TriplyDB

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

http://www.wikidata.org/entity/Q42816260

about

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Mechanisms of hepatic fibrogenesis Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid.The PXR is a drug target for chronic inflammatory liver disease.Serine/threonine protein kinase SGK1 in glucocorticoid-dependent transdifferentiation of pancreatic acinar cells to hepatocytes.Targeting the pregnane X receptor in liver injury.Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells MRP8/ABCC11 expression is regulated by dexamethasone in breast cancer cells and is associated to progesterone receptor status in breast tumors.Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration Focus on therapeutic strategies of nonalcoholic Fatty liver disease Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.Molecular Interactions between NAFLD and Xenobiotic Metabolism.Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.Nuclear receptors as drug targets in cholestatic liver diseases.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies Environmental Xenoestrogens Super-Activate a Variant Murine ER Beta in Cholangiocytes.Fibrogenesis in nonalcoholic steatohepatitis.Pregnane X receptor polymorphisms associated with human diseases.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.The stellate cell system (vitamin A-storing cell system).Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia.Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.Expression of CYP2S1 in human hepatic stellate cells.Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis

P2860

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P2860

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

http://www.wikidata.org/entity/Q42816260

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

@zh-tw

2005年论文

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2005年论文

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2005年论文

@zh-cn

name

Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.

@en

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR

@nl

type

label

Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.

@en

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR

@nl

prefLabel

Pregnenolone-16alpha-carbonitr ...... nd PXR-independent mechanisms.

@en

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR

@nl

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P932

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P1433

Biochemical Journal

P1476

Pregnenolone-16alpha-carbonitr ...... and PXR-independent mechanisms

@en

P2093

Bryan Goodwin

http://www.w3.org/2001/XMLSchema#string

Carylyn J Marek

http://www.w3.org/2001/XMLSchema#string

Dee Haefner

http://www.w3.org/2001/XMLSchema#string

Dimitrios K Konstantinou

http://www.w3.org/2001/XMLSchema#string

Graeme I Murray

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Lucy J Elrick

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Steven J Tucker

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P2860

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

Transcription factors in liver development, differentiation, and regeneration

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

Identification of a truncated ratp28-related protein expressed in kidney.

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.

P304

601-608

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scholarly article

P356

10.1042/BJ20041598

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P407

P433

Pt 3

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P478

387

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P50

Charalambos Sigalas

Matthew C. Wright

P577

2005-05-01T00:00:00Z

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P698

15595924

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P932

1134989

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