Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
about
Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain.Hirschsprung disease and other enteric dysganglionoses.Molecular mechanisms of RET activation in human neoplasia.Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastomaThe sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis.Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Multiple endocrine neoplasia type 2 syndromes may be associated with renal malformations.Melanoma development and pigment cell transformation in xiphophorus.The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease.Predominant RET Germline Mutations in Exons 10, 11, and 16 in Iranian Patients with Hereditary Medullary Thyroid Carcinoma.Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.Advances in the management of hereditary medullary thyroid cancer.RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors.Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases.Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2.Advances in molecular genetics of Hirschsprung's disease.Central role of RET in thyroid cancer.Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations.Inducible dimerization of RET reveals a specific AKT deregulation in oncogenic signaling.Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones.Increase in hepatocyte growth factor receptor tyrosine kinase activity in renal carcinoma cells is associated with increased motility partly through phosphoinositide 3-kinase activation.Association of RET protooncogene codon 45 polymorphism with Hirschsprung disease.The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease.Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A-associated medullary thyroid carcinoma.Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.
P2860
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P2860
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@en
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@nl
type
label
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@en
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@nl
prefLabel
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@en
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@nl
P2093
P356
P1433
P1476
Dual effect on the RET recepto ...... ic extracytoplasmic cysteines.
@en
P2093
Chappuis-Flament S
Ségouffin-Cariou C
P2888
P304
P356
10.1038/SJ.ONC.1202202
P407
P577
1998-12-01T00:00:00Z
P5875
P6179
1008087116