about
Early alterations of brain cellular energy homeostasis in Huntington disease modelsCystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's diseaseCorticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degenerationCorrection: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian PrimatesSerial 1H-NMR spectroscopy study of metabolic impairment in primates chronically treated with the succinate dehydrogenase inhibitor 3-nitropropionic acid.1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.Energy defects in Huntington's disease: Why "in vivo" evidence matters.Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.Normal aging modulates the neurotoxicity of mutant huntingtin.Restricted transgene expression in the brain with cell-type specific neuronal promoters.Quantitative assessment of transcriptome differences between brain territories.In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtinIRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primatesAge-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.Engineered lentiviral vector targeting astrocytes in vivo.Ectosomes: a new mechanism for non-exosomal secretion of tau protein.Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study.3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo.Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging.New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis.A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtinDiscovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease.Mitochondria in Huntington's disease.Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin.Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?Sustained effects of nonallele-specific Huntingtin silencing.Implication of the JNK pathway in a rat model of Huntington's disease.Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Emmanuel Brouillet
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Emmanuel Brouillet
@en
Emmanuel Brouillet
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Emmanuel Brouillet
@nl
Emmanuel Brouillet
@sl
type
label
Emmanuel Brouillet
@ast
Emmanuel Brouillet
@en
Emmanuel Brouillet
@es
Emmanuel Brouillet
@nl
Emmanuel Brouillet
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altLabel
Brouillet E
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E Brouillet
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prefLabel
Emmanuel Brouillet
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Emmanuel Brouillet
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Emmanuel Brouillet
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Emmanuel Brouillet
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Emmanuel Brouillet
@sl
P1053
B-4784-2014
P106
P21
P31
P3829
P4012
P496
0000-0001-6322-7403