about
Deleted in Colorectal Cancer (DCC) encodes a netrin receptorUNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathwaysUNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx modelVAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans.The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegansFunctional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans.C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IVGenetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response.Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme.The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.Functions of netrins and semaphorins in axon guidance.Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans.Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans.UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.Axon guidance mechanisms in Caenorhabditis elegans.EXAMINATION OF NEURONS IN WILD TYPE AND MUTANTS OFCAENORHABDITIS ELEGANSUSING ANTIBODIES TO HORSERADISH PEROXIDASEVulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midlineDCC and netrinsExpression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Joseph Culotti
@ast
Joseph Culotti
@en
Joseph Culotti
@es
Joseph Culotti
@nl
Joseph Culotti
@sl
type
label
Joseph Culotti
@ast
Joseph Culotti
@en
Joseph Culotti
@es
Joseph Culotti
@nl
Joseph Culotti
@sl
prefLabel
Joseph Culotti
@ast
Joseph Culotti
@en
Joseph Culotti
@es
Joseph Culotti
@nl
Joseph Culotti
@sl
P106
P1153
7004375384
P21
P31
P496
0000-0001-6325-4612