Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.
about
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationThe Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceRegulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegansUNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway.Distinct cell guidance pathways controlled by the Rac and Rho GEF domains of UNC-73/TRIO in Caenorhabditis elegansPolarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis.A pre- and co-knockdown of RNAseT enzyme, Eri-1, enhances the efficiency of RNAi induced gene silencing in Caenorhabditis elegans.Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.Another morphogenetic movement on the map: Charting dorsal intercalation in C. elegans.Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D.The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.
P2860
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P2860
Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@ast
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@en
type
label
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@ast
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@en
prefLabel
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@ast
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@en
P2860
P1476
Functional analysis of the Cae ...... tro and axon guidance in vivo.
@en
P2093
Terrance J Kubiseski
Tony Pawson
P2860
P304
P356
10.1128/MCB.23.19.6823-6835.2003
P407
P577
2003-10-01T00:00:00Z